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TNFα和IL-1β是机体损伤后活化的巨噬细胞最先分泌的两种细胞因子。许多细菌性感染的表现均和这些多肽的释放有关。IL-6可能是巨噬细胞、内皮细胞和其它细胞被IL-1β和TNFα活化后释放出的第二信使。为确定IL-1β、TNFα和IL-6与感染尤其是中毒性休克的关系,对严重细菌性感染患者血清中这些细胞因子的变化进行了研究。研究对象是外科ICU收治的40名感染病人,其中腹腔感染20名,纵隔炎5例,支气管肺炎3例,败血症9人,
TNFα and IL-1β are the first two cytokines secreted by activated macrophages after injury. Many bacterial infections are associated with the release of these polypeptides. IL-6 may be the second messenger that is released by macrophages, endothelial cells and other cells activated by IL-1β and TNFα. To determine the association of IL-1β, TNFα and IL-6 with infections, especially toxic shock, the changes of these cytokines in sera of patients with severe bacterial infections were studied. The study was performed in 40 surgical patients admitted to the ICU, including 20 with abdominal infection, 5 with mediastinitis, 3 with bronchial pneumonia, 9 with sepsis,