多民族的研究显示HLA-DQ基因同胰岛素依赖型糖尿病(IDDM)易感性相关。本研究采用多聚酶链式反应(PCR)和序列特异性寡核苷酸探针杂交(SSOPH)方法,对北京地区汉族49例IDDM患者及48例健康对照者HLA-DQA 1及HLA-DQB 1基因进行研究。结果表明:(1)HLA-DQA 1基因的A 4等位基因(RR=11.7,Pc<0.02)与IDDM易感性呈显著正相关;(2)HLA-DQB 1基因的DQB 1 0601(DQw1.12)等位基因与IDDM抵抗性相关(RR=0.03,Pc<0.002),(3)HLA-DQβ57天门冬氨酸(HLA-DQβ 57 AsP~+) Multi-ethnic studies have shown that HLA-DQ genes are associated with insulin-dependent diabetes mellitus (IDDM) susceptibility. In this study, HLA-DQA 1 and HLA-DQB 1 genes were detected in 49 idiopathic IDDM patients and 48 healthy controls in Han nationality in Beijing using polymerase chain reaction (PCR) and sequence-specific oligonucleotide probe hybridization (SSOPH) research. The results showed that: (1) A 4 allele of HLA-DQA 1 gene (RR = 11.7, Pc <0.02) was positively correlated with IDDM susceptibility; (2) DQB 1 0601 (DQw1) 12) alleles were associated with IDDM resistance (RR = 0.03, Pc <0.002), (3) HLA-DQβ57 aspartate