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用放射免疫法检测41例大肠癌患者和20树结肠炎患者血清CEA、CA19-9、SF含量。结果显示：大肠癌三项标记物测定值均明显高于对照组（P＜0．01）。三项指标中除CEA在A_2期较高外，基本符合病理进展程度越深，肿瘤标记物检出率越高的特点。组织学分类中CEA阳性率粘液腺癌＞乳头状腺癌，CA19-9粘液腺癌＞管状腺癌＞乳头状腺癌，SF则管状腺癌明显＞乳头状腺癌（P＜0．05）。三项标记物联合检测时其敏感性、特异性、准确性为90．2％、75．0％、85．2％。
The serum CEA, CA19-9 and SF levels in 41 patients with colorectal cancer and 20 patients with 20 colitis were detected by radioimmunoassay. The results showed that the three markers of colorectal cancer were significantly higher than the control group (P<0.01). Among the three indicators, with the exception of CEA in the A 2 phase, the higher the degree of pathological progression, the higher the detection rate of tumor markers. CEA positive rates in histological classifications were mucinous adenocarcinoma> papillary adenocarcinoma, CA19-9 mucinous adenocarcinoma> tubular adenocarcinoma> papillary adenocarcinoma, SF was tubular adenocarcinoma> papillary adenocarcinoma (P < 0.05) . The combined sensitivity, specificity, and accuracy of the three markers were 90.2%, 75.0%, and 85.2%.