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青蒿素(1)的结构和绝对构型已经确定.由于它有七个手性中心,所以在研究其降解物结构或其全合成时,遇到许多立体化学上的问题.本文报道用核磁共振的去偶和NOE技术研究青蒿素降解物(2、6和8)和青蒿素B降解物(4)以及全合成中间体(3、5、6、7、9、10和11)构型的结果.化合物1～11的化学位移结果见表1. 内酯环构型内酯从六员降为五员时,其氧键应与C_6相连(1→6);核磁共振未见带氧质子信号,
The structure and absolute configuration of artemisinin (1) has been determined, and due to its seven chiral centers, many stereochemical problems have been encountered in studying the structure of its degradants or their total synthesis.In this paper, Resonance decoupling and NOE techniques were used to study artemisinin degradation products (2,6 and 8) and artemisinin B degradation products (4) as well as total synthesis of intermediates (3,5,6,7,9,10 and 11) Configuration results. The chemical shift results of compounds 1 to 11 are shown in Table 1. The lactone ring configuration lactone reduced from six to five, the oxygen bond should be connected with C_6 (1 → 6); NMR no seen With proton signal,