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目的系统评价糖脉康辅助治疗2型糖尿病(T2DM)对血糖相关指标的改善效果,为中医药治疗T2DM提供循证医学参考。方法以糖脉康、中药复方制剂、西医降糖药物、2型糖尿病为中文检索词,以Tang Mai Kang、Tangmaikang、antidiabetic drugs、hypoglycemic agents、granule of traditional Chinese medicine、traditional Chinese medicine granules、diabetes mellitus、T2DM、diabetes mellitus type 2、diabetes patient、diabetes mellitus patient、type 2 diabetes mellitus、T2DM为英文检索词,计算机检索中国生物医学文献数据库、中国期刊全文数据库、万方数字化期刊全文数据库及中文科技期刊数据库数据库、Medline、EMBASE、The Cochrane Library等,收集糖脉康辅助治疗与西医治疗T2DM疗效对比的随机对照文献,提取纳入研究的特征信息。用Revman5.2软件进行Meta分析,比较糖脉康辅助治疗与西医治疗对空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A_(1c))的效果。结果共纳入10篇文献。采用糖脉康辅助治疗2个月时T2DM患者的FBG(95%CI为-0.62~-0.33)及治疗3个月时的2 h PG(95%CI为-0.84~-0.47)、Hb A_(1c)(95%CI为-0.45~-0.22)均低于采用西医降糖药物者(P均<0.01)。结论采用糖脉康辅助治疗的T2DM患者FBG、2 h PG、Hb A_(1c)均低于采用西医降糖药物者。
Objective To systematically evaluate the effect of Tangmaikang adjuvant therapy on type 2 diabetes mellitus (T2DM) on blood glucose-related indicators and provide evidence-based medicine for the treatment of T2DM by Chinese medicine. Methods Tang Mai Kang, Tangmaikang, antidiabetic drugs, hypoglycemic agents, granule of traditional Chinese medicine, traditional Chinese medicine granules, diabetes mellitus, T2DM, diabetes mellitus type 2, diabetes patient, diabetes mellitus patient, type 2 diabetes mellitus, type 2 diabetes mellitus, T2DM English search term, computerized Chinese biomedical literature database, Chinese Journal Full-text Database, Wanfang Digital Periodicals Full-text Database and Chinese Science and Technology Periodical Database Database , Medline, EMBASE, The Cochrane Library, etc. We collected randomized controlled literature comparing the effect of Tangmaikang adjuvant therapy with western medicine in the treatment of T2DM and extracted the characteristic information of the included study. Meta-analysis was performed using Revman5.2 software to compare the effects of Tangmaikang adjuvant therapy with western medicine on fasting blood glucose (FBG), postprandial 2h blood glucose (PG), and glycosylated hemoglobin (Hb A_ (1c)). Results A total of 10 articles were included. FBG (95% CI -0.62 ~ -0.33) and 2 h PG (95% CI -0.84 ~ -0.47) at 3 months after treatment with Tangmaikang adjuvant therapy for 2 months in T2DM patients, Hb A_ 1c) (95% CI: -0.45-0.22) were lower than those with western medicine hypoglycemic agents (all P <0.01). Conclusions FBG, 2 h PG and Hb A 1c in T2DM patients treated with Tangmaikang are lower than those in patients receiving Western medicine.