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目的对新生儿败血症临床特征及病原菌的构成、抗药性进行系统分析。方法对2012年9月~2015年9月在深圳市龙岗区中心医院儿科治疗的35例患有败血症的新生儿临床资料进行回顾分析。结果研究表明,新生儿败血症临床症状无特异性;大肠埃希菌在致病菌构成中比例最大;药敏实验表明绝大多数菌株对氨苄西林、青霉素有耐药性;对大部分第Ⅰ、Ⅱ代头孢菌素类药物有耐药性;对第Ⅲ代头孢菌素、舒巴坦、奎若酮类等较为敏感;对万古霉素、替考拉宁及亚胺培南均有很高的敏感度。结论新生儿败血症的临床特征无任何特异性,革兰氏阳性菌是主要的病原菌,临床治疗中应加强药敏试验,根据实际结果选用抗菌药物,确保临床疗效。
Objective To analyze the clinical features of neonatal sepsis and the constitution and drug resistance of pathogens. Methods The clinical data of 35 neonates with sepsis treated in pediatric department of Longgang Central Hospital from September 2012 to September 2015 were retrospectively analyzed. Results The study showed that neonatal sepsis clinical symptoms non-specific; Escherichia coli in the pathogens constitute the largest proportion; drug sensitivity test showed that the vast majority of strains of ampicillin, penicillin resistance; for most of the first, The second-generation cephalosporins are resistant to the third-generation cephalosporins, sulbactam, quinolones and other more sensitive to vancomycin, teicoplanin and imipenem are high Sensitivity. Conclusion The clinical features of neonatal sepsis have no specificity. Gram-positive bacteria are the main pathogenic bacteria. Drug susceptibility testing should be strengthened in clinical treatment. Antibacterial drugs should be selected according to the actual results to ensure clinical efficacy.