前列腺素E_2(PGE_2)及其它多种前列腺素能防止各种有害物质对胃粘膜的损害。作者用Fisher及Hunt方法测定口服PGE_2对防止乙酰水杨酸所致胃微量出血的作用。 6名健康志愿受试者年龄18～42(平均27)岁。经禁食一夜后于次日上午9时从口腔插入一外径为6mm的薄氯乙烯导管直至齿下55cm处,此时,导管前端已进入胃。通过导管向胃内滴入蒸馏水100ml,令受试者收缩腹肌,使身体沿纵轴转动,然后将水排出。检查分3次进行,每次历时10分钟,在每次试验后均再次滴入100ml蒸馏水,洗胃后将液体排出,接 Prostaglandin E_2 (PGE_2) and many other prostaglandins prevent various harmful substances from damaging gastric mucosa. The authors used Fisher and Hunt methods to determine the effect of oral administration of PGE 2 on the prevention of gastric hypohydrolysis induced by acetylsalicylic acid. Six healthy volunteers ranged in age from 18 to 42 (mean, 27) years. One night after fasting, a 6-mm-thick vinyl chloride catheter was inserted from the mouth into the stomach at 9:00 am the next day until it was 55 cm below the tooth. At this point, the leading end of the catheter had entered the stomach. 100 ml of distilled water was dripped into the stomach through the catheter, causing the subject to contract the abdominal muscles, rotate the body along the longitudinal axis, and then drain the water. Check points 3 times, each time lasted 10 minutes, after each test are again dripped 100ml distilled water, gastric lavage after the liquid discharge, then