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平阳霉素自发现以来一直作为抗肿瘤的一线用药得到人们的广泛关注。近年来,将平阳霉素制备成微球剂型,改变其体内代谢过程,延长药物的作用时间,增强平阳霉素的疗效成为医药学界的研究热点。本文首先通过平阳霉素与博来霉素的对比体现出平阳霉素的优势;之后对平阳霉素的临床应用、不良反应等方面进行了相关介绍,经总结得出平阳霉素具备高效低毒的特点;最后对平阳霉素微球研究的最新进展进行了概括,并提出了该药物在未来应用方面的展望。
Pingyangmycin has been widely used as a first-line anti-tumor medicine since its discovery. In recent years, the preparation of pingyangmycin into microsphere dosage form, changing its metabolism process, prolonging the acting time of the medicament and enhancing the curative effect of pingyangmycin become the research hotspot of medical science. This paper first Pingyangmycin and Bleomycin comparison shows the advantages of Pingyangmycin; Pingyangmycin after clinical application, adverse reactions and other aspects of the introduction, concluded that Pingyangmycin with high efficiency and low toxicity Finally, the recent progress on the research of pingyangmycin microspheres was summarized, and the prospect of its application in the future was put forward.