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问1:干扰素和核苷类似物各有何优缺点?答:干扰素主要针对免疫调节,早期治疗的时候转氨酶一段时间可能比较高,DNA下降幅度不像核苷类似物这么快,但是e抗原血清学转换比较高,表面抗原的消失或者转换相对低一点,另外疗程有限,基本固定是一年,现在有延长的趋势。现在对于普通干扰素大家公认四到六个月,聚乙二醇干扰素延长 Question 1: What are the advantages and disadvantages of interferon and nucleoside analogues? A: Interferon is mainly for immune regulation, early treatment of transaminases may be relatively high for a period of time, DNA decline is not as fast as nucleoside analogues, but e Antigen seroconversion is relatively high, the disappearance of surface antigen or conversion is relatively low, the other treatment is limited, the basic fixed for one year, there is now an extension of the trend. Pegasys are now extended for about four to six months now for common interferons
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