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Objective:To evaluate the clinical efficacy of the treatment with rolling needle or rolling needle combined With Beifuji And compared with the blank group among 93 patients suffered from the crow’s feet, Preliminary discuss the mechanism of they treat wrinkles, and study the method of minimally invasive treatment wrinkles in traditional Chinese medicine.Methods:Choose the young crowd crow’s feet seeking beauty 93 cases were randomly divided into treatment groupⅠ(32 cases), treatment groupⅡ(30 cases) and control group (31 cases). Treatment groupⅠusing rolling needle combined With Beifuji, treatment groupⅡusing rolling needle, two groups of treatment time all for once every seven days. Control group has any treatment measures, who only ask seeking beauty keeping regular life. Three groups are for every 28 days 1 treatment, compare and analysis after the treatment of three courses.Results:Through 3 courses of treatment, the treatment groupⅠ(rolling needle combined With Beifuji group) 14 cases markedly effective,12 cases improved,5 cases of ineffective, total effective rate was 83.87%; Treatment groupⅡ(rolling needle group) 5 cases markedly effective,18 cases improved,7 cases of ineffective, total effective rate was 76.67%; The control group (blank control group) all patients were invalid. There were not clinical cure cases in three groups. Compared three groups of the total effective, The difference was significant (P< 0.01). Compared treatment groupⅠwith treatment groupⅡof the total effective rate,there were differences (P<0.05). There are 13 effect-acting cases in the first treatment periods in treatment groupⅠ, there are 5 effect-acting cases in the first treatment periods in treatment groupⅡ, there were differences (P<0.05).Conclusion:rolling needle combined With Beifuji and rolling needle to young crowd crow’s feet are stitches has good clinical curative effect, the former slightly better than the latter. Neither of them has side effects they are worth of being generalized in clinical.