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The discovery of electron leak pathways of the mitochondrial respiratory chain inspires us to investigate human health with a new insight of bioenergetics and bioinformation.The fact is that the ROS generated in the electron leak pathways of mitochondrial respiratory chain have two opposite effects on the human body:the negative effect of ROS is causing disease and aging;the positive effect of ROS is playing as the signal to stimulate the antioxidative function and to strengthen the ability of damage repairing,this is a reconstructive process of the health state of human body.