Oncogenic herpesvirus KSHV is known to encode four viral interferon regulatory factors(vIRF1-4)to subvert host antiviral immune response,but their detailed DNAbinding profiles as transcription factors in host remain uncharacterized.Here we first performed the genome-wide vIRF2-binding sites mapping in human genome using chromatin immunoprecipitation coupled to high-throughput sequencing(ChIP-seq).