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Weaned pigs often face postweaning challenges,including diarrhea,impaired growth rate,and low feed intake.Antimicrobial peptides (AMPs) are small gene-encoded peptides that show a broad range of activity against bacteria,fungi,and mycobacteria.Thus,AMPs have potential values in improving growth performance and health of weaned pigs.A total of 2250 pigs from 5 pig farms (450 pigs each) were weaned at 28 d of age (7.98±0.23 kg average BW) and randomly assigned to 1 of 3 treatments during a 32-d feeding experiment,including 1) a basal diet (control); 2) 2 g/kg of AMPs (AMP-2) and 3) 3 g/kg of AMPs (AMP-3).Each treatment had 15 replicated pens with 10 pigs per pen in each farm.The AMPs used in the present study were a mixture of lactoferrin,cecropin,defensin and plectasin.Pigs had free access to feed and drinking water at all times throughout the experimental period.Pigs in AMP-2 and AMP-3 groups had greater ADG than pigs in control group.ADFI tended to be greater in pigs fed 2 g/kg of AMPs than pigs fed control diet.Pigs fed 2 g/kg or 3 g/kg AMPs also tended to have increased G:F compared with pigs fed control diet.The survival rates were increased in AMP-2 and AMP-3 groups compared with the control group.These results indicate that dietary supplementation with AMPs could improve growth performance and survival of weaned piglets.