【摘 要】
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Coumarins have wide application in the fields of bromatology,materials and medicinal chemistry.Thiazole in a variety of clinically antibacterial drugs can easily bind with various biomolecules in orga
【机 构】
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School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715
【出 处】
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中国化学会第十六届全国有机合成化学学术研讨会
论文部分内容阅读
Coumarins have wide application in the fields of bromatology,materials and medicinal chemistry.Thiazole in a variety of clinically antibacterial drugs can easily bind with various biomolecules in organisms through noncovalent interactions,thus exhibiting multi-targeting potential.Hydroxyethyl fragment plays a crucial role in the phase of exerting biological effect,which is widely present in many medicinal drugs such as disinfectant ethanol,antibacterial metronidazole,antifungal fluconazole and so on.Here a series of coumarin skeleton-based three-component hybrids by the combination of thiazole ring and diethanolamine fragment were first designed and synthesized,and their biological behaviour was evaluated with the aim to discover novel type of multi-targeting antimicrobial agents for overcoming drug resistance.
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