Accelerated proliferation of cancer cells is linked to increased transcription of rDNA by RNA polymerase I(Pol I)to produce elevated levels of rRNA for ribosomal biogenesis.
The continued emergence of drug-resistant pathogens is a global public health problem.With the increasing antibiotic resistance of bacteria,there is an obvious need for alternative therapeutics and ma
Drug-resistant bacteria pose an urgent public-health crisis.Over the years,β-lactams were the antibiotics of choice for treatment of S.aureus infections1.
β-Lactam antibiotics are widely used in the treatment of bacterial infections.However,The overuse of antibiotics leads to the emergence of drug-resistant bacteria,which has posed a great threat to hum
The drug-resistant bacteria have been a serious threat to the clinical treatment.These bacteria hydrolyze almost all β-lactam antibiotics by expressing the metallo-β-lactamses(MβLs).
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep