【摘 要】
：
Neurological complications associated with HIV-1 are being recognized as a common commonly disorder in AIDS patients,especially patients with HIV-associated dementia (HAD).However,our knowledge of the
【机 构】
：
Pharmacy Department,Third Affiliatedaffiliated Hospital,Medical university of Guangzhou Medical Univ
论文部分内容阅读
Neurological complications associated with HIV-1 are being recognized as a common commonly disorder in AIDS patients,especially patients with HIV-associated dementia (HAD).However,our knowledge of the complicated pathogenesis andclinical symptoms of HAD is limited by an incomplete understanding of the biology of HIV-1 in the nervous system.Therefore,this review focuses on the pathogenesis of HAD in the context of novel highly active antiretroviral therapy (HARRT) regimens.HIV-D).It developed with the infiltration of HIV-1 into the nervous system.Research of HIV-D is necessary to understand the impact and the biology of HIV-1 in the nervous system for its complicated pathogenesis and clinical symptom.Future studies might focus on identify new technology platforms to develop antiretroviral drugs.
其他文献
目的:探讨哈蟆油(oR)对D-半乳糖所致雌性衰老大鼠肝脏组织p16、p21和cyclinD1蛋白表达的影响,进一步探讨OR延缓雌性大鼠机体衰老机制.方法：SPF级SD雌性青年大鼠40只随机分为模型组(D-gal组)、维生素E(VE组)、哈蟆油高剂量组(OR-H组)、中剂量组(OR-M组)、低剂量组(OR-L组),每组8只,D-半乳糖颈背部皮下注42d,建立亚急性衰老模型.另取雌性青年大鼠8只,同样
目的：研究芹菜素与柚皮素分别经大鼠空肠、回肠与结肠黏膜的体外区段透过特征.方法：采用体外垂直扩散池(Ussing Chamber)方法,分别评价50 μmol·L-1芹菜素及柚皮素经空肠、回肠和结肠黏膜经时(O～120min)吸收方向(M-S)与分泌方向(S-M)的累计透过率,并通过体系稳态时间(60min-120min)的累计透过率计算各区段吸收方向与分泌方向的表观渗透系数(Papp).芹菜素与
Purpose:The aim of this study was to test the ability of paclitaxel-loaded poly(butyl) cyanoacrylate (PBCA) nanoparticles to overcome multidrug resistance (MDR) in human ovarian resistant cells (A2780
Bone marrow mesenchyrnal stem cells (BMSC) can differentiate into diverse cell types,including adipogenic,osteogenic,chondrogenic and myogenic lineages.There are lots of BMSC accumulated in atheroscle
目的:探讨复方姜黄合剂对糖尿病大鼠视网膜新生血管的干预效果,并研究其剂量一疗效的关系.方法:STZ(链脲佐菌素)诱导糖尿病大鼠成功后,实验鼠随机分为合剂低剂量组、合剂中剂量组、合剂高剂量组、模型组、羟苯磺酸钙组,并设正常对照组.合剂组和羟苯磺酸钙组分别用复方姜黄合剂和羟苯磺酸钙,模型组和对照组用等容量蒸馏水灌胃.20周后,将实验大鼠处死.取眼球行视网膜消化铺片,观察血管形态,微血管数目,计算每高倍
Backbround:Venlafaxine is a new antidepressant that has a chemical structure and neuropharmacologic profile distinct from those of existing antidespressants.The studies about the mechanism of pharmaco
The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways.α-Secretase cleaves APP within β amyloid protein (Aβ) sequence,resulting in the release of a
A new and simple high performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) method for determination of Kryptofix 2.2.2 (K-222) in the radiopharmaceuticals of 2-deoxy-2-[
本文将从表达重组P450s的宿主细胞及表达质粒、N-末端修饰、培养宿主温度与周期、分子伴侣共表达和纯化重组细胞色素酶P450s方法等方面对用E.coli表达人源P450s的近期进展进行综述.得出：细胞色素酶P450，能够催化各种内源性和外源性物质包括药物、致癌物和其他异源化学物质的氧化代谢。基于这种性质，P450s在医学和生物技术领域具有广泛的应用前景，可以作为药物靶点和药物生物合成及开发药物的新
硫酸酯化多糖对幽门螺旋杆菌具有较高亲和力.本研究合成了具有潜在幽门螺旋杆菌亲和能力的果胶硫酸酯,采用傅里叶红外变换光谱仪对其进行结构确证.建立了氯化钡明胶比浊法测量果胶硫酸酯取代度的方法,该法准确度及线性良好,测定合成的果胶硫酸酯取代度为0.116.在此基础上,初步考察了酯化试剂用量、保护气体以及透析液对果胶硫酸酯化反应的影响.