【摘 要】
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To investigate the effects of endosulfan on coagulation status and its mechanism, 32male wistar rats were randomly divided into four groups including a control solution and three concentrations of end
【机 构】
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School of Public Health,Beijing Key Laboratory of Environmental Toxicology, Capital Medical Universi
【出 处】
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首都医科大学公共卫生学院第四届研究生学术论坛
论文部分内容阅读
To investigate the effects of endosulfan on coagulation status and its mechanism, 32male wistar rats were randomly divided into four groups including a control solution and three concentrations of endosuifan groups (1, 5, 10 mg/kg/day).Results showed that endosulfan significantly promoted platelet aggregation, prolonged thrombin time and increased D-dimer level,decreased fibrinogen level; promoted the expressions of Fas, caspase-8, caspase-3 in vascular endothelial cell.The resulted suggested that endosulfan could cause hypercoagulability of blood by promoting both platelet aggregation and transformation of fibrinogen into fibrin.Endosulfan could induce the endothelial cells dysfunction resulting from oxidative stress.
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The purpose of this work was to investigate the blood toxicity of different dosages of endosulfan in Wistar rats.The experiment was composed of four groups: the control group did not receive any endos