Outline Definition and Epidemiology Clinical Presentation and outcomes Diagnosis Treatment principles and options Future directionsAmyloidosis-Definition Extracellular tissue deposition of fibrils composed of low molecular weight subunits of various proteins (normally present in the blood)Fibrils misfold → beta-pleated sheet configuration· characteristic EM appearance· bind Congo red (green birefringence under polarized light)· bind Thioflavine T (yellow-green fluorescence)