Infectious caused by intracellular pathogens,such as viral,bacterial and parasites have been a serious worldwide public health concern and affected millions of people annually.Unlike extracellular pathogens,the defense and prevention of intracellular pathogen infections are more difficult since the pathogen could be protected from host immune responses and certain antibiotic therapies.Therefore,its important to develop advanced treatment to better fight intracellular infections.Nanomedicine may be a promising approach for treatment of intracellular pathogens.For intracellular bacterial eradication,the challenge lies in the design of nanoparticles that are specifically and differentially adhered and taken up by the targeted cells and release their antimicrobial load in an extended period to achieve a clinical response.In this study,we present the development of advanced drug delivery systems by integrating an adhesion peptide sequence and a targeting moiety to biodegradable nanoparticles to specifically target and internalize into osteoblasts for potential intracellular pathogen elimination.