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To study whether the TM-induced ER stress causes memory deficits,spontaneous activity,anxiety and depression behavior change in rats by electric platform test,open field test,forced swimming test and high plus maze test and the related molecular mechanisms.Simultaneously,detected the signaling molecules related CREB to investigate the possible molecular mechanisms.In this study,TM was injected in the left lateral ventricle and the model replication was same to the part Ⅰ,after 24 and 48 hours later,behavior tests were detected and the number of neuron,type of dendritic spines,the level of glutamate receptors and synaptic related proteins and CREB associated signaling molecules in different brain region.