A Phase Ⅱ Randomized,Double-Blind,Multicenter,Based on Standard Therapy,Placebo-Controlled Study of

来源 :The 2014 International Symposium on Clinical and Translation | 被引量 : 0次 | 上传用户：xiedavid

【摘要】

：

OBJECTIVES The purpose of this study was to assess the safety and efficacy of recombinant human neuregulin-1rhNRG-1)in chronic heart failure(CHF)patients.Backgr

【作者】

：

Runlin Gao Jian Zhang Liuquan Cheng Xuesi Wu Wei Dong Xinchun Yang Tianchang Li Xifu Liu Yabei Xu Xinyan Li Mingdong Zhou

【机构】

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CardiovascularInstituteandFuwaiHospital,ChineseAcademyofMedicalSciences,BeijingGeneralHospitalofChin

【出处】

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The 2014 International Symposium on Clinical and Translation

【发表日期】

：

2014年5期

【关键词】

：

Recombinant human neuregulin-1 CHF double-blind randomized phase Ⅱ study

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OBJECTIVES The purpose of this study was to assess the safety and efficacy of recombinant human neuregulin-1rhNRG-1)in chronic heart failure(CHF)patients.Background Neuregulin-1 plays important roles in maintaining cardiomyocyte structure and cardiac pumping functionality and physiology.Previously,rhNRG-1 was proven to be effective in treating heart failure in animals by reducing enddiastolic volume(EDV)and end-systolic volume(ESV)and increasing left ventricular ejection fraction(LVEF％).

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