Objective:Ovarian cancer has the highest mortality rate of the gynecological cancers.Although cisplatin (CDDP),is effective treatment for ovarian cancer,recurrence is frequent and leads to death.It is implied that cellular resistance to cisplafin is either inherent or acquired during the treatment;however,the underlying molecular mechanisms are still not well established.The role of PAF/PAFR in tumors has been investigated in recent years.