Antifungals from Plant Extracts and the Niches in Veterinary Medicine

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户:duchze
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  Due to increasing resistance of fungi against conventional drugs,as well as the observable side effects of the already limited numbers of antifungals commonly used in veterinary practice,the fungal infections among animals,whether superficial or systemic,often pose substantial management problems and are still a major concern.In addition,the expense that entails most treatment regimens often complicates the problems further via an impact on the decision not only which drug to use,but also how much drug to use and for how long,in order to achieve successful therapeutic outcome for a given animal species.In this regards,the alternative "herbal formulations" have become a recent and renewed interest.Medicinal plants are in fact an integral part of ethnoveterinary medicine and the practice is rather common in China,India,Japan,Mexico,Pakistan,Sri Lanka and Thailand.Development in information technology has facilitated an explosion in the range and content of electronic information concerning medicinal plants as a re-emergent health aid for both animals and humans.It has been estimated that more than 100,000 plants/plant extracts have been assayed for their antifungal activities.Applying the IC50< 100 μ g/ml as a cut-off value if the extracts would possess any promising therapeutic value,the potential candidates are categorized based on the active constituent and indigenous plants of certain regions.Examples of herbal formulation and the efficacy testing are presented.Clinical benefits and possible drawbacks are also discussed.
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