Objective: Ginger has been widely used as healthy food condiment as well as traditional Chinese medicine since antiquity.Multiple potentials of ginger for treatment of various ailments have been revealed recently.However, the biological half-life of 6-gingerol (a principal pungent ingredient of ginger) is only 7.23 minutes while orally taken in vivo.The investigation on delivery access of ginger compositions beside oral have been reported scarcely.Therefore, we studied the noninvasive transdermal drug delivery system (TDDS) of ginger to bypass hepatic first pass metabolism, avoid gastrointestinal degradation and achieve long persistent release of effective compositions.