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目的:对普萘洛尔治疗婴幼儿血管瘤的临床疗效和不良反应进行评价。方法 :68例血管瘤患儿每天口服普萘洛尔1.0～1.5 mg/kg,分3次服用。瘤体消失或稳定15～30 d后逐渐停药。采用SPSS13.0软件包中的Ridit检验对血管瘤类型、部位与疗效进行比较。结果:68例患儿平均疗程7.1个月,平均随访时间16.7个月。I级疗效3例、Ⅱ级15例、Ⅲ级28例、Ⅳ级19例,无效2例。结论:普萘洛尔治疗婴幼儿血管瘤安全有效,应作为婴幼儿血管瘤的一线治疗。
Objective: To evaluate the clinical efficacy and adverse reactions of propranolol in the treatment of infantile hemangiomas. Methods: A total of 68 hemangiomas were treated with propranolol 1.0 ~ 1.5 mg / kg every day for 3 times. The tumor disappeared or stabilized gradually after 15 ~ 30 d. The Ridit test in SPSS13.0 software package was used to compare the type, location and curative effect of hemangiomas. Results: The average course of treatment in 68 children was 7.1 months with a mean follow-up time of 16.7 months. Grade I curative effect in 3 cases, Ⅱ grade in 15 cases, Ⅲ grade in 28 cases, Ⅳ grade in 19 cases, invalid in 2 cases. Conclusion: Propranolol is safe and effective for the treatment of infantile hemangiomas and should be taken as first-line treatment for infantile hemangiomas.