胃泌素自从1964年由Gregory等首次从猪的胃窦粘膜提取出来后,才正式确认为是一个胃肠激素。过去认为它仅存在于幽门窦和十二指肠近端。最近。丹麦的Larsson和Rehfeld报道:在垂体细胞及其提取物中发现有胃泌素存在。作者在猫和猪的垂体和下丘脑用区域特异性免疫细胞化学和放射免疫测定法,发现垂体前叶的ACTH细胞和中间叶的α-MSH细胞具有特异的胃泌素反应性。在前叶,只分散在某些细胞;在中间叶,则所有细胞都有。此外,在垂体柄和神经叶发现有一定数量的、具有胃泌素免疫反应性的神经末梢,但在以上各处,并未发现有CCK免疫反应性。同时,对垂体各部位进行胃泌素含量的测定,结果表 Gastrin has been formally identified as a gastrointestinal hormone since it was extracted from porcine antral mucosa by Gregory et al. In 1964. In the past that it exists only in the pylorus sinus and proximal duodenum. recent. Larsson and Rehfeld, Denmark, report that gastrin is found in pituitary cells and their extracts. Using region-specific immunocytochemistry and radioimmunoassay in the pituitary and hypothalamus of cats and pigs, the authors found that α-MSH cells in the anterior pituitary ACTH cells and in the middle leaves have specific gastrin responsiveness. In the anterior leaflet, only some cells are scattered; in the middle leaf, all cells are present. In addition, a number of nerve endings with gastrin immunoreactivity were found in the pituitary stalk and nerve lobes, but no CCK immunoreactivity was found in all of the above. At the same time, all parts of the pituitary gastrin determination, the results table