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目的:观察和评价中药杀胚方剂对甲氨蝶呤(MTX)联合米非司酮保守治疗未破裂型输卵管妊娠的辅助作用。方法:将118例未破裂型输卵管妊娠病例分为A、B2组,A组使用MTX+米非司酮+中药联合治疗;B组使用MTX+米非司酮治疗,定期监测血β-HCG及附件区包块大小变化,同时记录不良反应发生情况。结果:总治愈率A组明显高于B组(P<0.05)。单疗程有效率A组高于B组但差异无显著性(P>0.05)。治疗后包块缩小速度(P<0.01)、血β-HCG转阴时间(P<0.05)和临床痊愈时间(P<0.01)A组均较B组明显缩短。胃肠道反应(P<0.01)、肝功能损害(P<0.05)发生率A组显著低于B组。结论:MTX+米非司酮+中药三联药物治疗未破裂型输卵管妊娠具有方法简捷、疗效高、疗程短、不良反应少、保留生育功能等优点,具有推广潜力和价值。
OBJECTIVE: To observe and evaluate the adjuvant effects of traditional Chinese medicine killing embryo on the conservative treatment of unruptured tubal pregnancy with methotrexate (MTX) and mifepristone. Methods: 118 cases of unruptured tubal pregnancy were divided into group A and group B2, group A was treated with MTX combined with mifepristone and traditional Chinese medicine. Group B was treated with MTX and mifepristone, and blood β-HCG and attachment region Changes in the size of mass, while recording the occurrence of adverse reactions. Results: The total cure rate in group A was significantly higher than that in group B (P <0.05). The effective rate of single treatment group A was higher than that of group B, but the difference was not significant (P> 0.05). After treatment, the reduction rate of mass (P <0.01), blood β-HCG negative conversion time (P <0.05) and clinical recovery time (P <0.01) in group A were significantly shorter than those in group B. Gastrointestinal reaction (P <0.01), liver damage (P <0.05) The incidence of A group was significantly lower than that of B group. Conclusion: MTX + mifepristone plus traditional Chinese medicine triple therapy for unruptured tubal pregnancy has the advantages of simple method, high efficacy, short course of treatment, less adverse reactions and retention of reproductive function, which has the potential and value to promote.