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目的 分析154例中央气道狭窄的病因构成,评估APC与联合冷冻治疗的疗效及安全性.方法 回顾2012年1月-2014年12月河南省人民医院呼吸科收治的中央气道良性狭窄的154例患者,分析其病因构成,随机分为APC与联合治疗组,分别为85例、69例.对比两组气道狭窄改善情况,治疗前后气喘症状及气促指数,并随访管腔再狭窄情况.结果 154例良性气管狭窄病因构成包括气管插管或气管切开术后狭窄97例(63.0％,其中气管插管58例,气管切开术后39例),气管结核29例(18.8％),良性肿瘤9例(5.8％),多软骨炎4例(3.2％),其他原因15例(9.1％).APC组共进行290次治疗,联合组共进行202次治疗,两组术后气道狭窄症状均明显改善,总有效率联合组94.2％(65/69)较APC组74.1％(63/85)高.经联合治疗后管腔通畅稳定时间较高频电刀组显著延长.结论 良性气管狭窄病因构成中气管插管和气管切开术后为最常见,其次是气管结核;在腔内介入治疗方面,联合治疗组比APC总有效率高,需要治疗的次数少,管腔稳定时间长.“,”Objective To analyze the causes of 154 benign tracheal stenosis and to evaluate the efficacy and safety of APC and associated with cryotherapy.Methods Totally 154 patients with benign central airway stenoses in our hospital from 2012.1 to 2014.12 were retrospectively analyzed.Patients were randomly treated by APC or combined with cryotherapy,respectively 85 cases and 69 cases.Contrast the improvement of the airway stenosis,and assessment the asthma symptoms and shortness of breath index before and after therapy,and follow-up the situation of the airway restenosis.Results Totally 154 cases of benign tracheal stenosis were recruited to our study.The main causes of benign tracheal stenosis were as follows:secondary to tracheal intubation or tracheotomy in 63％ (tracheal intubation 58,tracheotomy 39).tuberculosis 18.8％ (29),benign tumor in 5.8％ (9),polychondritis in 3.2％ (4)and other 9.1％.APC group were totally treated 290 times,the combined treatment group 202 times,the airway stenosis of the two groups postoperative were significantly improved,the total effective rate of combined treatment group was 94.2％ (65/69) and in the APC was 74.1％ (63/85).The airway stability time treated by the two ways was significantly longer than the APC group.Conclusion In the causes constituents of the benign tracheal stenosis,tracheal intubation and tracheotomy is common,followed by tracheal tuberculosis;In interventional therapy,the total effective rate of the combined treatment is higher than APC,fewer treatment numbers and maintained longer.