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报道了用戊型肝炎（ＨｅｐａｔｉｔｉｓＥ，ＨＥ）病人粪便悬液感染恒河猴后的组织病理学、血液生化与免疫学以及病毒学分子生物学检测的结果。三只实验猴在感染后第３～４周均出现ＡＬＴ异常；粪便以及肝脏与胆囊组织超薄切片中电镜观察到２７～３４ｎｍ大小的病毒样颗粒；病理组织切片观察表明，肝脏组织有典型的急性炎症病灶；粪便与血清经ＲＴｎＰＣＲ扩增到戊型肝炎病毒（ＨｅｐａｔｉｔｉｓＥＶｉｒｕｓ，ＨＥＶ）特异性片段，粪便排毒从感染后第７天持续至第５０天左右，病毒血症迟于粪便排毒，出现于感染后两周左右，维持１～２周；ＥＬＩＳＡ检测发现，实验猴血清中ＨＥＶＩｇＧ抗体水平在感染后３～４周阳转，４～５个月后转阴。这些实验结果提示，恒河猴作为ＨＥＶ感染实验动物模型是理想的，建立系统的恒河猴实验模型对探讨ＨＥＶ感染发病机理、机体免疫应答以及临床诊断与疫苗研制具有重要意义。
Reported the results of histopathology, blood biochemistry and immunology, and virological molecular biology tests of rhesus monkeys infected with fecal fluid from patients with Hepatitis E (HE). ALT abnormalities were observed in all three experimental monkeys from the third week to the fourth week after infection. The size of 27 ~ 34nm virus-like particles was observed by electron microscopy in feces and liver and gallbladder sections. The histological sections showed that the liver tissues were typical Acute inflammatory lesions; excrement and serum by RT nPCR amplified to hepatitis E virus (HepatitisEVirus, HEV) specific fragments, excretion detoxification from the first 7 days after infection until about 50 days, viremia later than detoxification, Appeared in about two weeks after infection, maintained for 1 to 2 weeks; ELISA test found that monkey serum HEVIgG antibody levels in 3 to 4 weeks after infection positive turn, 4 to 5 months after the turn negative. These results suggest that rhesus monkeys as HEV infection experimental animal model is ideal, the establishment of a systematic experimental model of rhesus monkeys to explore the pathogenesis of HEV infection, immune response and clinical diagnosis and vaccine development is of great significance.