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应用自动化图像分析仪对低剂量α－双炔失碳酯（ＡＮＯ）诱导ＨＬ－６０细胞分化的作用进行了形态测量研究。４μｇ／ｍｌＡＮＯ连续作用ＨＬ－６０细胞５天。共测８个形态指标。结果表明，细胞面积：核面积，核周长，核最大直径，核最小直径，核灰度／核面积随药物作用时间增加而增大，而核浆比却随时间增加而减小。所有数据表明，在低剂量ＡＮＯ（４μｇ／ｍｌ）作用下，ＨＬ－６０细胞在１～４天内作为细胞生命基本的ＤＮＡ变化显著，但细胞形态基本稳定。第５天开始呈现显著性地向成熟细胞转化的倾向。
The morphometric study of the effects of low-dose α- anordyne (ANO)-induced differentiation of HL-60 cells was performed using an automated image analyzer. HL-60 cells were continuously treated with 4 μg/ml ANO for 5 days. A total of 8 morphological indicators were measured. The results showed that the cell area: nuclear area, nuclear perimeter, maximum nuclear diameter, nuclear minimum diameter, nuclear grayscale/nuclear area increased with the increase of drug action time, but the nuclear-to-plasma ratio decreased with time. All data showed that under low-dose ANO (4 μg/ml), HL-60 cells showed significant DNA changes in cell life within 1 to 4 days, but cell morphology was basically stable. Day 5 began to show a significant tendency to transform into mature cells.