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目的:研究细胞周期依赖性蛋白激酶3(CDK3)在鼻咽癌中的表达及其与临床病理因素的关系,探讨其临床意义。方法:用免疫组织化学方法检测94例鼻咽癌组织中CDK3的表达,以40例鼻咽炎组织为实验对照。结果:94例鼻咽癌组织中CDK3的阳性表达率达67.0%,对照组40例鼻咽炎组织中CDK3的阳性表达率为12.5%,CDK3在鼻咽癌组织的表达显著高于在鼻咽炎的表达(P<0.05)。CDK3主要表达于鼻咽癌细胞质,少数表达于核内。CDK3蛋白表达与鼻咽癌TNM分期有关(P<0.01)。结论:CDK3在鼻咽癌中表达增高,并与鼻咽癌TNM分期有关,提示CDK3蛋白在鼻咽癌的发生和发展过程中可能发挥作用。
Objective: To investigate the expression of CDK3 in nasopharyngeal carcinoma and its relationship with clinicopathological factors, and to explore its clinical significance. Methods: The expression of CDK3 in 94 cases of nasopharyngeal carcinoma tissues was detected by immunohistochemistry, and 40 cases of nasopharyngitis tissues were used as experimental control. Results: The positive rate of CDK3 in 94 cases of nasopharyngeal carcinoma was 67.0%. The positive rate of CDK3 in 40 cases of nasopharyngitis was 12.5% in control group, while the expression of CDK3 in nasopharyngeal carcinoma was significantly higher than that in nasopharyngitis Expression (P <0.05). CDK3 is mainly expressed in the cytoplasm of NPC, a few expressed in the nucleus. The expression of CDK3 protein was correlated with the TNM staging of nasopharyngeal carcinoma (P <0.01). Conclusion: CDK3 is highly expressed in nasopharyngeal carcinoma and is related to TNM staging of nasopharyngeal carcinoma. It suggests that CDK3 may play a role in the occurrence and development of nasopharyngeal carcinoma.