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目的观察复方玄驹胶囊、克罗米芬联合戊酸雌二醇治疗多囊卵巢综合征合并不孕患者(肾阳虚型)的临床疗效。方法选择桂林市妇幼保健院生殖中心2015年收治的93例多囊卵巢综合征患者(肾阳虚型),随机分为观察组46例与对照组47例,观察组患者采用克罗米芬、戊酸雌二醇联合复方玄驹胶囊进行治疗,对照组患者采用克罗米芬联合戊酸雌二醇治疗。结果观察组与对照组在女方年龄、不孕年限、促卵泡成熟激素(FSH)、促黄体生成激素(LH)、睾酮(T)、体质量指数(BMI)、男方年龄及前向运动精子方面比较,差异均无统计学意义(均P>0.05);两组排卵数、流产率、宫外孕率及多胎率比较,差异均无统计学意义(均P>0.05);观察组患者在h CG日内膜厚度、妊娠率与对照组比较,差异均有统计学意义(均P<0.05)。结论复方玄驹胶囊在克罗米芬联合戊酸雌二醇行多囊卵巢综合征合并不孕患者(肾阳虚型)促排卵治疗时辅助用药,可以提高患者的子宫内膜厚度及临床妊娠率。
Objective To observe the clinical efficacy of compound xuanju capsule and clomiphene combined with estradiol valerate in patients with polycystic ovary syndrome complicated with infertility. Methods Ninety-three cases of polycystic ovary syndrome (Shen Yang Deficiency) admitted to Reproductive Center of Guilin MCH Hospital in 2015 were randomly divided into observation group (46 cases) and control group (47 cases). Patients in observation group were treated with clomiphene citrate Estradiol combined with xuanju capsule for treatment, the control group patients with clomiphene combined with estradiol valerate. Results The observation group and the control group had significant differences in age, duration of infertility, FSH, LH, T, BMI, (All P> 0.05). There was no significant difference in the number of ovulation, miscarriage rate, ectopic pregnancy rate and multiple pregnancy rate between the two groups (all P> 0.05) Intimal thickness, pregnancy rate compared with the control group, the difference was statistically significant (P <0.05). Conclusion Compound Xuanju Capsule in the clomiphene combined with estradiol valerate polycystic ovary syndrome patients with infertility (kidney yang deficiency type) ovulation induction treatment, can improve the patient’s endometrial thickness and clinical pregnancy rate.