神经胶质瘤的治疗至今尚无明显进展 ,肿瘤生物治疗的一个新策略———诱导分化疗法为这一难题的解决提供了一个新途径。目前应用于胶质瘤的分化诱导剂主要有极性化合物、维A类化合物、芳香脂肪酸、环腺苷酸衍生物和细胞因子等。作为一种改进和补充胶质瘤常规治疗的新方案 ,诱导分化疗法具有良好的应用前景。本文对该领域的实验和临床研究进展作一综述 No obvious progress has been made in the treatment of gliomas so far. A new strategy of tumor biotherapy-induced differentiation therapy provides a new way to solve this problem. Currently used in glioma differentiation inducer mainly polar compounds, Victoria A class compounds, aromatic fatty acids, cyclic adenosine acid derivatives and cytokines. As a new method to improve and supplement the conventional treatment of glioma, the induction of differentiation therapy has good application prospects. This article reviews the progress of experimental and clinical research in this area