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蛛网膜下腔出血(SAH)后经常发生脑血管痉挛,发病机理不清。有人提出是儿茶酚胺或肽能神经系统的作用。然而,已注意到SAH后脑血管内皮细胞有广泛的变性或坏死。因此,脑血管痉挛也可能是由于损伤的内皮细胞释放血管活性化合物作用于脑血管引起的反应。目前,强有力的血管绩肽,即内皮素(endothelin),已经从猪和人的内皮细胞分离和鉴定。为了更好的解释内皮素在脑血管痉挛发病机理中的作用,作者对住院手术后2.2±2.0天的26名SAH患者,连续收集116次脑脊液(CSF)标本,对内皮素进行放射免疫测定。结果表明:内皮
Subarachnoid hemorrhage (SAH) often occurs after cerebral vasospasm, the pathogenesis is unclear. It has been suggested that catecholamines or peptides can play a role in the nervous system. However, extensive denaturation or necrosis of cerebrovascular endothelial cells has been noted after SAH. Therefore, cerebral vasospasm may also be caused by the release of vasoactive compounds from the injured endothelium in the cerebrovascular response. Currently, a potent vascular peptide, endothelin, has been isolated and identified from porcine and human endothelial cells. In order to better explain the role of endothelin in the pathogenesis of cerebral vasospasm, the authors collected 116 cerebrospinal fluid (CSF) specimens from 26 SAH patients who were hospitalized for 2.2 ± 2.0 days and performed radioimmunoassay on endothelin. The results show that: endothelial