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背景:目前造血干细胞移植主要依靠在非血缘关系供者中寻找相合者。非亲缘造血干细胞捐献者的心理状态对于保证顺利完成移植,使受者得到有效治疗非常重要。目的:比较亲缘及非亲缘供者造血干细胞采集前后心理及生理健康状态。方法:分别在入院时,采集前(1 d),采集后(一两天),1个月后回访4个时间点对亲缘与非亲缘供者的心理状态(SCL-90症状自评量表评分)及一般生理指标(体温,呼吸,脉搏,血压)进行评估比较。结果与结论:在入院时,亲缘与非亲缘供者的心理健康水平差异无显著性意义(P>0.05);而在采集前、采集后,非亲缘供者的SCL-90总分、强迫、抑郁、焦虑、敌对、恐惧分值高于亲缘供者(P<0.05);1个月后回访,大多数分值差异无显著性意义(P>0.05)。非亲缘和亲缘供者的生理指标平稳,但在采集前和采集后2个时间点,两组供者呼吸和收缩压差异有显著性意义。提示非亲缘供者在采集过程中的心理负荷较高,应给予针对性情绪疏导指导和心理防护。
Background: At present, hematopoietic stem cell transplantation mainly relies on looking for partners in non-blood donors. The psychological status of unrelated hematopoietic stem cell donors is very important for ensuring successful transplantation and effective treatment of recipients. Objective: To compare the psychological and physiological status of hematopoietic stem cells collected from relatives and unrelated donors. Methods: The psychological status of relatives and unrelated donors (SCL-90 Symptom Check List 90) was retrospectively analyzed before admission (1 d), after collection (one day or two days) and after 1 month Score) and general physiological indicators (body temperature, respiration, pulse, blood pressure) were compared. RESULTS AND CONCLUSION: There was no significant difference in mental health status between relatives and non-related donors at admission (P> 0.05). However, SCL-90 scores of non-related donors, before and after collection, The scores of depression, anxiety, hostility and fear were higher than those of relatives (P <0.05). After 1 month of follow-up, most of the scores showed no significant difference (P> 0.05). Physiological indices of non-relatives and relatives were stable, but there were significant differences in respiration and systolic blood pressure between the two groups before and at two time points after collection. Suggesting that non-related donor in the acquisition process of psychological load is higher, should be targeted counseling and emotional counseling and psychological protection.