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[目的]观察化湿活血汤联合甲钴胺治疗2型糖尿病下肢周围神经病变疗效。[方法]使用随机平行对照方法,将113例住院患者按病志号抽签方法简单随机分为两组。对照组56例甲钴胺500ug,1次/d,肌注,出院后甲钴胺片,0.5mg/次,3次/d,口服。治疗组57例化湿活血汤(黄芪30g,苍术、白术各15g,薏苡仁30g,黄芩、丹参各15g,独活、赤芍各10g,鸡血藤30g,地龙10g,川牛膝15g,甘草6g),水煎服,1剂/d,水煎80m L,早晚分服;甲钴胺治疗同对照组。连续治疗28d为1疗程。观测临床症状、麻木、疼痛、感觉障碍、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效24例,有效26例,无效7例,总有效率87.82%。对照组显效14例,有效26例,无效16例,总有效率45.61%。治疗组疗效优于对照组(P<0.05)。[结论]化湿活血汤联合甲钴胺治疗2型糖尿病下肢周围神经病变,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Huashi Huoxue Decoction combined with mecobalamin on peripheral neuropathy of lower extremity in type 2 diabetes mellitus. [Methods] Using randomized parallel control method, 113 inpatients were randomly divided into two groups randomly according to the method of lot drawing. Control group, 56 cases of mecobalamin 500ug, 1 times / d, intramuscular injection, mecobalamine tablets after discharge, 0.5mg / time, 3 times / d, orally. In the treatment group, 57 cases of Huashi Huoxue Decoction (Astragalus 30g, Atractylodes, Atractylodes 15g, Coix Seed 30g, Scutellaria baicalensis, Radix Scutellariae 15g each, live alone, red peony root 10g, Millettia 30g, earthworm 10g, 6g), Shuijianbi, 1 / d, decoction 80m L, morning and evening sub-service; mecobalamin treatment with the control group. Continuous treatment 28d for a course of treatment. Observed clinical symptoms, numbness, pain, sensory disturbances, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Result] The treatment group was effective in 24 cases, effective in 26 cases, ineffective in 7 cases, the total effective rate was 87.82%. In the control group, 14 cases were markedly effective, 26 cases were effective, 16 cases were ineffective and the total effective rate was 45.61%. The treatment group was better than the control group (P <0.05). [Conclusion] Huashi Huoxue Decoction combined with mecobalamin in the treatment of peripheral neuropathy of lower extremities in type 2 diabetes mellitus has satisfactory curative effect and no serious adverse reactions, which is worth promoting.