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目的探讨曲美他嗪联合常规抗心力衰竭药物治疗老年患者左室舒张功能不全的效果。方法老年左室舒张功能不全患者97例,随机分为对照组(49例)和曲美他嗪组(48例)。观察治疗前后心率、血压、临床症状,超声检测左室射血分数(LVEF)和左室短轴缩短率(FS),左室舒张末内径(LVEDD)、左心室充盈分数(LVRFF)及二尖瓣快速充盈期/心房收缩期血流速度(E/A)的变化。结果治疗后两组临床症状均有改善,但曲美他嗪组明显优于对照组,曲美他嗪组显效率37%,总有效率96%(P<0.01);治疗后两组心率、血压均无明显变化;LVEF、FS、LVEDD、LVRFF和E/A均有所增加(P<0.01),两组间比较曲美他嗪组较对照组更为显著(P<0.05)。结论老年左室舒张功能不全患者在常规治疗基础上加用曲美他嗪治疗,能够有效改善老年患者的左心室舒张功能,且无明显不良反应。
Objective To investigate the effect of trimetazidine combined with conventional anti-heart failure drugs on left ventricular diastolic dysfunction in elderly patients. Methods A total of 97 elderly patients with left ventricular diastolic dysfunction were randomly divided into control group (49 cases) and trimetazidine group (48 cases). Before and after treatment, heart rate, blood pressure, clinical symptoms, left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (FS), left ventricular end diastolic diameter (LVEDD), left ventricular filling fraction (LVRFF) Rapid filling of the valve / atrial systolic blood flow velocity (E / A) changes. Results After treatment, the clinical symptoms of both groups were improved, but the trimetazidine group was significantly better than the control group, trimetazidine group was 37%, the total effective rate was 96% (P <0.01); after treatment, heart rate, Blood pressure had no significant changes; LVEF, FS, LVEDD, LVRFF and E / A were increased (P <0.01). The trimetazidine group was more significant than the control group (P <0.05). Conclusions Elderly patients with left ventricular diastolic dysfunction combined with trimetazidine treatment on the basis of routine treatment can effectively improve left ventricular diastolic function in elderly patients with no obvious adverse reactions.