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目的 :观察抗纤软肝颗粒对实验性肝纤维化时肝组织 型胶原 ( - C)、层粘蛋白 (L N)以及肝窦毛细血管化的影响。方法 :大鼠皮下注射 2 5 0 m l/ L CCl4 制备肝纤维化模型 ,并同时给于秋水仙碱、抗纤软肝颗粒小和大剂量治疗 ,用光镜和电镜观察肝组织病理变化 ,免疫组织化学法检测肝组织 - C、L N。结果 :抗纤软肝颗粒能有效抑制 - C、L N的生成和沉积 (P <0 .0 1) ,改善肝纤维化大鼠肝组织病理变化 (P <0 .0 1) ,减轻肝窦毛细血管化程度。结论 :抗纤软肝颗粒能抑制肝窦毛细血管化的形成 ,产生抗肝纤维化的作用。
Objective : To observe the effect of Kangxian Ruangan Granules on hepatic tissue-type collagen (-C), laminin (LN) and hepatic sinusoidal capillarization during experimental hepatic fibrosis. METHODS: Liver fibrosis model was established by subcutaneous injection of 250 ml/L CCl4 in rats, and simultaneously given to colchicine and anti-fibrosis liver granules in small and large doses. Pathological changes of liver tissues were observed by light and electron microscopy. Histochemical detection of liver tissue - C, LN. Results: Kangxian Ruangan granules can effectively inhibit the formation and deposition of -C and LN (P < 0.01), improve liver pathological changes in liver fibrosis rats (P <0. 01), and reduce liver sinusoidal capillaries The degree of vascularization. Conclusion: Kangxian Ruangan Granule can inhibit the formation of hepatic sinusoidal capillarization and produce anti-hepatic fibrosis.