慢性粒细胞白血病(CGL)可以多个系列急变,本文报道3例CGL急性巨核细胞变,每例均经血小板和巨核细胞糖蛋白Ⅱb/Ⅲa抗原特异性单克隆免疫染色阳性所证实。3例慢性期细胞形态学及染色体均提示典型CG-L,急性期末梢及骨髓瑞氏染色示胞浆偶见颗粒,白血病细胞大小不等;骨髓活检大量巨核细胞内含丰富嗜酸性胞浆及不同程度骨髓纤维化,网状结构增生。细胞化学:过氧化酶阴性,氯化醋酸酯酶阴性,α-萘酚丁酸酯酶阴性,末端脱氧核苷酸酶阴性,甲苯胺蓝 Chronic myeloid leukemia (CGL) can be a series of rapid changes in the paper reported in 3 cases of CGL acute megakaryocyte changes, each case by platelet and megakaryocyte glycoprotein Ⅱ b / Ⅲ a antigen-specific monoclonal immunostaining confirmed. 3 cases of chronic phase cell morphology and chromosome prompted typical CG-L, acute peripheral and bone marrow Wright’s staining showed occasional cytoplasmic granules, leukemia cell size; a large number of bone marrow biopsy megakaryocytes containing rich eosinophilic cytoplasm and Different degrees of myelofibrosis, reticular proliferation. Cytochemistry: Peroxidase negative, Chloroacetate negative, α-Naphtholbutyrate negative, Terminal deoxynucleotidyl negative, Toluidine blue