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目的探讨CyclinD1、Cdk6在子宫内膜腺癌中的表达与临床意义。方法应用免疫组织化学,检测30例正常子宫内膜及30例不典型增生子宫内膜和45例子宫内膜腺癌中的CyclinD1与Cdk 6蛋白的表达情况。结果 CyclinD1与Cdk 6在不典型增生子宫内膜和子宫内膜腺癌中的表达率与正常子宫内膜组相比有统计学意义(P<0.05),与子宫内膜腺癌的分化程度,Dukes分期及淋巴结转移呈正相关关系(P<0.05)。结论 CyclinD1与Cdk 6蛋白的过度表达可能在子宫内膜癌的发生、发展、浸润中起重要作用,对判断子宫内膜腺癌的预后有一定的临床意义。
Objective To investigate the expression and clinical significance of CyclinD1 and Cdk6 in endometrial adenocarcinoma. Methods Immunohistochemistry was used to detect the expression of CyclinD1 and Cdk 6 in 30 cases of normal endometrium, 30 cases of atypical hyperplasia and 45 cases of endometrial adenocarcinoma. Results The expression rates of CyclinD1 and Cdk 6 in atypical hyperplasia endometrium and endometrial adenocarcinoma were significantly higher than those in normal endometrium (P <0.05), but not in endometrial adenocarcinoma, Dukes staging and lymph node metastasis were positively correlated (P <0.05). Conclusion The overexpression of CyclinD1 and Cdk 6 proteins may play an important role in the development, progression and invasion of endometrial carcinoma, and may be of clinical significance in judging the prognosis of endometrial adenocarcinoma.