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为防制动物布鲁氏菌病(以下简称布病),成功地研制出了布鲁氏菌(以下简称布氏菌)羊种M_5弱毒疫苗和猪种S_2弱毒疫菌等,并进行了大面积的推广应用,对牛、羊、猪、鹿等动物布病的防制起了具大的作用,经济效益和社会效益十分显著,但是存在的问题是布氏菌自然感染和菌苗免疫的鉴别,因为人畜应用活菌苗以后所产生的各种血清学反应和自然感染所产生的各种血清学反应极其相似。鉴别诊断不仅关系着布病的防治工作,同时对流行病学调查也具有重要意义,这也是布病防治领域的难题之一。多年来,国内外学者为解决这一具有战略意义的课题,在建立不同种类的检测方法,分析布氏菌免疫和感染的机体体液中的不同类型免疫球蛋白抗体出现的时间、在数量上的差别和动态上的关系,以及制备和纯化各种布氏菌的抗原等方面进行了广泛深入的研究。
In order to prevent brucellosis in animals (hereinafter referred to as brucellosis), we successfully developed the M_5 attenuated vaccine against brucellosis (hereinafter referred to as brucellosis) and S_ The promotion and application of the area have played a significant role in the prevention and control of brucellosis in animals such as cattle, sheep, pigs and deer, and have obvious economic and social benefits. However, the existing problems are the natural infection of B. brucei and the immunity of the vaccine Identification, because the human and livestock after the application of live vaccine produced by the various serological reactions and natural infection produced by the various serological reactions are very similar. Differential diagnosis is not only related to the prevention and treatment of brucellosis, but also of great significance for epidemiological investigation, which is also one of the problems in the field of brucellosis prevention and treatment. Over the years, domestic and foreign scholars to address this strategic issue, the establishment of different types of detection methods to analyze the immune and infectious body fluids of B. burgdorferi different types of immunoglobulin antibodies in the body appeared in time, in quantity Differential and dynamic relationship, as well as the preparation and purification of various antigens of Brucella and other aspects of a wide range of in-depth study.