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用放射性免疫测定方法,检测大黄对家兔体温中枢附近脑室灌流液内环核苷酸(cAMP)的影响,结果表明,大黄使感染性发热家兔cAMP水平降低,而对正常不发热家兔cAMP水平没有影响。对照组动物cAMP水平没有变化。提示大黄降温作用机理之一是通过影响中枢cAMP水平而实现的。
Radioimmunoassay was used to detect the effect of rhubarb on the cyclic nucleotide (cAMP) in the ventricles of rabbits near the body temperature center. The results showed that rhubarb reduced the cAMP levels in rabbits with infectious fever, but it did not produce cAMP in rabbits with normal fever. Level has no effect. There was no change in cAMP levels in the control animals. It is suggested that one of the mechanisms of cooling effect of rhubarb is achieved by affecting the level of central cAMP.