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非洋地黄类正性肌力药近年来,非洋地黄类正性肌力药物发展迅速,为危重心功能衰竭(心衰)和难治性心衰病人的治疗开辟了一条新途径。目前临床上应用较广的有以下几种。β受体兴奋剂本类药物主要通过兴奋心脏β受体,激活腺苷酸环化酶(adenylate cyclase,AC),使三磷酸腺苷(ATP)转化为环磷酸腺苷(cAMP),促进钙离子(Ca~(2+))进入心肌细胞膜,选择性地增加心肌收缩力,增加心输出量和降低肺毛细血管楔压,改善心
Non-digitalis Inotropic Agents In recent years, non-digitalis inotropic agents have developed rapidly, opening up a new avenue for the treatment of critically ill patients with heart failure and refractory heart failure. Currently widely used in clinical have the following. β receptor agonists of these drugs mainly through the excitement of cardiac β receptor, activation of adenylate cyclase (ACY), the three adenosine triphosphate (ATP) into cAMP, promote calcium (Ca ~ (2+)) into the myocardial cell membrane, selectively increase myocardial contractility, increase cardiac output and reduce pulmonary capillary wedge pressure, improve heart