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应用人精子与去透明带金黄地鼠卵受精技术制备人精子染色体标本。对10例有自然流产史妇女的丈夫共230个精子核型进行了分析,并与正常可育男性的210个核型对照。结果显示,流产组的精子染色体数目异常率为39%,与正常组相比(28%),两者无显著性差异(P>0.05);但流产组中结构异常的断裂和无着丝粒断片的比率(60%;95%)显著性高于对照组(25%;28%)。
Preparation of Human Sperm Chromosomes Using Human Spermatozoa and the Golden Hamster Oocyte Fertilization Technique. A total of 230 sperm karyotypes were analyzed for the husband of 10 women with a history of spontaneous abortion and compared with 210 karyotypes of normal fertile men. The results showed that the abortion rate of sperm chromosome number was 3.9%, compared with the normal group (2. 8%), there was no significant difference (P> 0.05); but the abortion group structural abnormalities The ratio of ruptured and non-centromeric fragments (60%; 95%) was significantly higher than that of the control group (2.5%, 2.8%).