论文部分内容阅读
目的探讨镇江地区汉族人群血清中微量元素浓度与前列腺癌发病的关系。方法 103例行前列腺手术治疗及穿刺活检的汉族男性患者为研究对象,记录患者病历资料并采集血清,检测微量元素铜、锌、铁、钙和镁含量。结果 103例患者中,前列腺癌44例(研究组),非前列腺癌59例(对照组)。血前列腺特异性抗原(PSA)>100 ng/ml的前列腺癌患者有16例,Gleason评分>8分的有29例。患者年龄为60~89岁,两组患者的年龄比较,差异无统计学意义(t=1.867,P>0.05)。研究组血铜含量高于对照组,血铁含量低于对照组,差异均具有统计学意义(t=3.597、4.358,P<0.05);两组患者的血锌、钙、镁含量比较,差异均无统计学意义(t=0.159、1.967、1.501,P>0.05);但血铜/锌比值和钙/镁比值比较,差异均具有统计学意义(t=3.225、2.866,P<0.05)。结论镇江地区汉族人群血清微量元素铜、锌、铁、钙和镁的浓度与前列腺癌的发生可能存在相关性。
Objective To investigate the relationship between serum trace elements concentration and the incidence of prostate cancer in Han nationality in Zhenjiang area. Methods A total of 103 Chinese Han male patients undergoing prostate biopsy and biopsy were enrolled in this study. Patient records were collected and serum was collected for the detection of trace elements copper, zinc, iron, calcium and magnesium. Results Among the 103 patients, there were 44 cases of prostate cancer (study group) and 59 cases of non-prostate cancer (control group). Sixteen patients had prostate cancer with a blood PSA> 100 ng / ml, and 29 patients had a Gleason score> 8. Patients aged 60 to 89 years old, two groups of patients age, the difference was not statistically significant (t = 1.867, P> 0.05). The blood copper content in the study group was higher than that in the control group, and the blood iron content was lower than that in the control group (t = 3.597, 4.358, P <0.05). There was significant difference in blood zinc, calcium and magnesium between the two groups (T = 0.159,1.967,1.501, P> 0.05). However, the differences of blood copper / zinc ratio and calcium / magnesium ratio were statistically significant (t = 3.225,2.866, P <0.05). Conclusion The concentration of serum trace elements copper, zinc, iron, calcium and magnesium in Han nationality in Zhenjiang area may be correlated with the occurrence of prostate cancer.