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目的观察银杏达莫联合黄芪对肾病综合征(NS)患者血液流变学的影响。方法选择2005-01-2010-0745例肾病综合征住院患者。治疗组用银杏达莫注射液25 ml加5%葡萄糖注射液250 ml,联合黄芪注射液30 ml加5%葡萄糖注射液250 ml静脉滴注,1次/d,15 d为1疗程,除一般对症治疗外,不用任何抗凝血药。对照组一般处理同治疗组,并常规给予阿司匹林80 mg,1次/d,疗程15 d。结果治疗组全血黏度、血浆黏度及血沉在治疗后均显著改善;胆固醇、甘油三酯均显著降低(P<0.05〉,高密度脂蛋白上升(P<0.05),对照组只有血小板聚集率明显下降(P<0.05),余无明显改善。结论银杏达莫联合黄芪对肾病综合征患者血液流变学有明显影响,改善肾病综合征患者高脂、高凝状态,抑制血栓形成从而改善微循环,保护肾功能,消除蛋白尿、水肿。
Objective To observe the effect of Ginkgo biloba combined with Radix Astragali on hemorrheology in patients with nephrotic syndrome (NS). Methods 2005-01-2010-0745 cases of nephrotic syndrome inpatients. The treatment group with ginkgo dipyridamole injection 25 ml plus 5% glucose injection 250 ml, combined Astragalus injection 30 ml plus 5% glucose injection 250 ml intravenous infusion, 1 / d, 15 d for a course of treatment, except in general Symptomatic treatment, without any anticoagulant. The control group generally treated with the treatment group, and routinely given aspirin 80 mg, 1 / d, course of treatment 15 d. Results The whole blood viscosity, plasma viscosity and erythrocyte sedimentation rate of the treatment group were significantly improved after treatment. The levels of cholesterol and triglyceride were significantly decreased (P <0.05) and the level of high density lipoprotein was increased (P <0.05) (P <0.05), and the rest did not improve significantly.Conclusion The combination of Ginkgo biloba and astragalus has a significant effect on hemorrheology in patients with nephrotic syndrome, improve the status of hyperlipemia and hypercoagulability in patients with nephrotic syndrome, inhibit thrombosis and improve microcirculation , Protect kidney function, eliminate proteinuria, edema.