【摘 要】
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The cell membrane features a variety of heterogeneous and dynamic compartments to regulate cell structure and function.These compartments are generally classifi
【机 构】
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Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Na
论文部分内容阅读
The cell membrane features a variety of heterogeneous and dynamic compartments to regulate cell structure and function.These compartments are generally classified into a relatively packed,lipidordered (Lo) domain (10-200 nm) enriched in saturated lipids and cholesterol,and a more fluid,liquid-disordered (Ld)domain comprising mainly unsaturated lipids [1].According to the lipid raft theory,Lo domains,which selectively recruit specific lipids and proteins,serve as critical platforms for signal transduction and membrane protein trafficking [2].There-fore,resolving the interplay and dynamics of lipids and proteins on the plasma membrane is of great importance to unveil the properties and biological relevance of membrane domains.
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