内皮素1是1988年日本学者Yanagisawa从猪主动脉内皮细胞培养液中分离纯化的一种活性肽,研究发现内皮素1不仅是收缩能力最强的血管收缩物质,而且具有多种生物学活性,对气道张力形成、细胞增殖与凋亡、离子转运、基因调控等均发挥多种生物学影响,近来发现内皮素1对神经系统的生理 Endothelin 1 is a kind of active peptide isolated and purified from pig aortic endothelial cell culture fluid by Japanese scholar Yanagisawa in 1988. It has been found that endothelin 1 is not only the vasoconstrictor with the most contractility but also has a variety of biological activities, On the airway tension formation, cell proliferation and apoptosis, ion transport, gene regulation and so play a variety of biological effects, have recently found that endothelin 1 on the nervous system physiology