研究发现慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期(AE-COPD)患者血清及痰中CRP[1]显著升高,并与病情发展严重程度呈正相关,说明CRP在COPD发病过程中贯穿始终,从而在COPD患者气道炎症的发生发展过程及气流阻塞中起至关重要的作用[2]。高同型半胱氨酸(Hcy)是心、脑及外周血管疾病的独立危险因素。研究发现COPD患者的血浆Hcy明显升高[3]。本研究拟观察血清 The study found that serum and sputum CRP [1] in patients with acute obstructive pulmonary disease (COPD) exacerbation (AE-COPD) was significantly increased, and was positively correlated with the severity of the disease progression, indicating that CRP in the pathogenesis of COPD Throughout the process, and thus play an important role in the occurrence and development of airway inflammation and airflow obstruction in COPD patients [2]. Homocysteine ​​(Hcy) is an independent risk factor for heart, brain and peripheral vascular disease. The study found that patients with COPD plasma Hcy was significantly increased [3]. This study intended to observe the serum