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合霉素结构中含有硝基基团,它可被还元后以亚硝酸钠法测其含量。在亚硝酸钠法滴定中,常以碘化钾淀粉试纸为外指示剂指示终点,此法有较多的缺点。作者们研究了用金莲橙OO((?))和次甲蓝为内指示剂,指示亚硝酸钠法滴定的终点以测定合霉素粉剂和栓剂中合霉素的含量的方法。1.合霉素粉剂测定法:大约0.5克样品(精密称定),置100ml锥形瓶中,加10ml浓盐酸及2.5克锌粉,(每隔两分钟加0.5克)。然后再加入10ml浓盐酸冲瓶壁,放置十五分钟。假如锌粉未
Coomycin structure contains nitro groups, it can be after the yuan to sodium nitrite method to measure its content. In the sodium nitrite titration, often with potassium iodide starch indicator for the external indicator of the end point, this method has more disadvantages. The authors investigated a method for the determination of the amount of Confocalcin in combolinomycin and suppositories using the end points of the sodium nitrite titration method, using the inner indicator of the lotus orange OO ((?)) And methylene blue. 1. Coimycin powder assay: About 0.5 grams of sample (accurately weighed), set 100ml conical flask, add 10ml of concentrated hydrochloric acid and 2.5 grams of zinc powder, (every 0.5 minutes add 0.5 grams). Then add 10ml concentrated hydrochloric acid washed bottle wall, place fifteen minutes. If the zinc powder is not